- This book contains creative and innovative ideas for rare-cell detection and isolation
- This book offers comprehensive discussions on the current understanding of the molecular biology of CTCs, as well as highly advanced and in-depth approaches for molecular characterization of these cells
- TThis book includes discussions on the potential clinical utility of CTCs and how these cells may be incorporated into routine medical practice and personalized medicine
Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.